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Certificate Course by Harvard on edX : Principles of Biochemistry MOOC

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Highlights

Disclaimer:Online Delivery via E-mail. No Physical Dispatch. Non-Cancellable Product
Stream:Medicine
Certification:Yes
Language:English
Format:MOOC
Type:Online Fulfillment
Duration:15 Weeks For queries and concerns drop an email to learning@snapdeal.com
SUPC: SDL456833052

Description

This course explores the molecules of life, starting with building blocks and culminating in complex metabolism and associated diseases.

About this course

Principles of Biochemistry integrates an introduction to the structure of macromolecules and a biochemical approach to cellular function. Topics addressing protein function will include enzyme kinetics, the characterization of major metabolic pathways and their interconnection into tightly regulated networks, and the manipulation of enzymes and pathways with mutations or drugs. An exploration of simple cells (red blood cells) to more complex tissues (muscle and liver) will be used as a framework to discuss the progression in metabolic complexity. Learners will also develop problem solving and analytical skills that are more generally applicable to the life sciences.

New in version 2, learners will explore how alteration of these metabolic pathways relates to the development and progression of some human diseases.

What you'll learn

The structure and function of the chemical building blocks of life

How to navigate protein structures using PyMOL

The central role of enzymes in catalyzing the reactions of life

The primary metabolic pathways that power cells

The intricate mechanisms that regulate cellular metabolism

The integration of biochemical processes in the context of cells, tissues, and whole organisms

How metabolic perturbations are linked to various human diseases

Course Syllabus

Unit 1: Introduction to biochemistry
âÂÂ Course introduction
âÂÂ Review of basic biochemistry

Unit 2: Structural biochemistry
âÂÂ Protein structure
âÂÂ Protein folding
âÂÂ Enzyme catalysis
âÂÂ Enzyme kinetics and iterative saturation mutagenesis
âÂÂ Lipid structure and membrane assembly

Human disease focus: lipodystrophy and lipid droplet pathologies
âÂÂ Carbohydrate structure

Unit 3: Cellular bioenergetics
âÂÂ Glycolysis
âÂÂ Unique features of glycolysis in red blood cells
âÂÂ Bacterial energetics
âÂÂ The citric acid and glyoxylate cycles
âÂÂ Electron transport
âÂÂ ATP synthesis
âÂÂ Regulation of glycolysis in liver cells
âÂÂ Regulation of blood sugar by the liver
Human disease focus: diabetes

Unit 4: Tissue-specific metabolism
âÂÂ Liver metabolism
âÂÂ Muscle metabolism
âÂÂ Brain metabolism
Human disease focus: PKU

Unit 5: Synthesis and degradation of biomolecules
âÂÂ Nucleic acids
âÂÂ Carbohydrate metabolism
Human disease focus: G6PD deficiency
âÂÂ Fatty acid metabolism
âÂÂ Human disease focus: cancer and cachexia

Meet the instructors

Alain Viel

Senior Lecturer, Department of Molecular and Cellular Biology

Harvard University

Rachelle Gaudet

Professor of Molecular and Cellular Biology

Harvard University

Terms & Conditions

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Brand: edX

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