Sky fruit is commonly used as herbal remedy that helps improve blood circulation, treat diabetes, and cure impotence. Many people have already used it and anecdotal reports have recorded the health benefits of the fruit. Besides, the revelation of various substances that the fruit contains may give reliable scientific clues of how efficacious the fruit is and how numerous sky fruit health benefits. Sky fruit benefits can be revealed by looking into the health effects of substances that the fruit contains. There are at least three active ingredients of sky fruit that are known to be beneficial for the health: flavonoid, saponin and alkaloids. We will look into the health benefits of the three active ingredients below. Flavonoid is a phenolic compound that contains many pigments of the plant. Flavonoid is beneficial for human especially because it is an antioxidant that exterminates free radicals and toxins and improves immune system.